Biotechnology

Biotechnology
Pharmaceutical, Food Science, Biomedical, Bioengineering Medical Devices

The multi-dimensional environment of biotechnology research and development ranges from developing new biocompatible implants, improving agricultural strains, to delivering better medicines. Whether it’s being able to image materials for healing tissue or plant vasculature, reliable results are needed for cost-effective development. ZEISS X-ray microscopy (XRM) provides quantitative non-destructive 3D tomography for unique opportunities to study specimens with high contrast and high resolution from the whole organism to the nanoscale. Data analysis of XRM characterization reveal a wealth of quantitative information in three dimensions. XRM is a powerful advanced characterization technique that can help bridge the current sample size, sample thickness, sample opaqueness gap and complement established imaging modalities such as confocal microscopy, histology and electron microscopy.

Characterization and Analysis

  • Perform permeability simulations using hydrogels as candidate biomaterials
  • Dissect and observe non-destructively, the 3D structure of inhalable (aerosol) pharmaceutical particles using nanoscale phase contrast XRM
  • Explore the 3D interface between mineralized tissue and metal implants to understand mechanical performance and biocompatibility
  • Characterize hierarchical block copolymers for biomedical scaffolds contextually in 3D and native environments prior to electron microscopy
  • Understand structural, compositional, and mechanical properties in scaffolds at orthopedic interfaces
  • Determine soybean susceptibility to manufactured nanomaterials with evidence for food quality and soil fertility interruption
  • Visualize nanoscale TiO2 accumulation in tetrahymena thermophila
  • Non-destructively image small medical parts and devices with sub-micron resolution
  • Aid biomedical studies on temporal bones in multi-channel cochlear implant

Systems

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ZEISS Xradia 520 Versa

High resolution, non-destructive 3D X-ray microscope with spatial resolution <700 nm (70 nm minimum voxel size), and resolution at a distance, with absorption and phase contrast enabled by a unique dual magnification system.
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ZEISS Xradia 810 Ultra

ZEISS Xradia 810 Ultra
Nanoscale X-ray Imaging:
Spatial resolution <50 nm (16 nm minimum voxel size) to support advanced semiconductor device research and development.
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Publications
Keywords
scaffolds, cochlear, implant, bone, attachment, hydrogels, biocompatibility